Most Patients With Prediabetes Don’t Know They Have Prediabetes.

What are indications that you might have diabetes or prediabetes? Diabetes develops very gradually, it could take up to several years. It follows that when you’re in the prediabetes stage, you may not have any symptoms at all. You may, however, notice that: • you eat a standard American processed food diet or • you’re […]

Prediabetes is a “Pre-Diagnosis” of Diabetes

Are you pre-diabetic? How can you tell? Can it be ignored?? Of all the chronic diseases currently known to mankind, diabetes is the most common. The onset of diabetes starts years before it becomes full-blown and starts affecting one’s health. How can you know if you are on the path to being a full-blown diabetic? […]

Inflammation and Its Outcomes

Despite it being an essential response to infection and tissue injury, inflammation has also been associated with several pathological processes. Excessive acute inflammation causes tissue damage and non-resolving inflammation leads to chronic tissue malfunction, suggesting a delicate balance between the rapid and effective response to distresses in tissue homeostasis and the collateral damage on tissue […]

Atherosclerosis or Atheroscleritis

Heart disease is currently one of the major causes of morbidity and correlates closely with the global incidence of obesity and type 2 diabetes. Recently, there is an increasing focus on metainflammation as the primary pathophysiology. Recent studies implicate early metabolic abnormalities (weight gain, insulin resistance, and prehypertension, and irregular blood lipid levels). A basic […]

Chronic Inflammation Metabolic Overfeed Hyperinsulinemia

Despite it being an essential response to infection and tissue injury, inflammation has also been associated with several pathological processes. Excessive acute inflammation causes tissue damage and non-resolving inflammation leads to chronic tissue malfunction, suggesting a delicate balance between the rapid and effective response to distresses in tissue homeostasis and the collateral damage on tissue […]

Insulin is The Link Between Adipose Tissue Inflammation and Metabolic Syndrome.

Hyperinsulinemia (HI) serves as the common link between adipose tissue inflammation (ATI) and metabolic syndrome. The obesity-associated metabolic phenotype elevated pro-inflammatory cells (M1 macrophages and NK-cells) suppressed anti-inflammatory cells (M2 macrophages, eosinophils, and regulatory T-cells). Partial reduction of circulating insulin level attenuated excess calorie-induced ATI and improved insulin sensitivity. Mol Cell Endocrinol. 2018 Dec 5;477:15-28. […]

Insulin is The Disease, Glucose is Just The Symptom.

For Type 2 Diabetes to occur, both insulin resistance and comparative inadequate insulin secretion must co-exist. For example, overweight individuals may have insulin resistance, but diabetes only develops in those who cannot increase insulin secretion sufficiently to compensate for their insulin resistance. Unfortunately, this period of hyperinsulinemia prior to the collapse of insulin production permits […]

About Complex System Failure

The failure of the to develop a “magic bullet” drug that safely promotes weight loss is evidence that a reductionist single biologic mechanism is unlikely to account for the obesity epidemic. We have conquered most of the communicable diseases, the next phase of medicine needs a systems approach. About complex system failure: Complex systems are […]

Titanium Dioxide (TiO2) Nanoparticles 28-1158 nm

Titanium dioxide (TiO2) nanoparticles are a commonly used whitening agent and have been considered an inert substance. It is classified as an Excipient (a pharmacologically inactive substance) by the FDA. In the pharmaceutical industry, TiO2 is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used […]