Most Patients With Prediabetes Don’t Know They Have Prediabetes.

What are indications that you might have diabetes or prediabetes? Diabetes develops very gradually, it could take up to several years. It follows that when you’re in the prediabetes stage, you may not have any symptoms at all. You may, however, notice that: • you eat a standard American processed food diet or • you’re… Continue reading Most Patients With Prediabetes Don’t Know They Have Prediabetes.

Prediabetes is a “Pre-Diagnosis” of Diabetes

Are you pre-diabetic? How can you tell? Can it be ignored?? Of all the chronic diseases currently known to mankind, diabetes is the most common. The onset of diabetes starts years before it becomes full-blown and starts affecting one’s health. How can you know if you are on the path to being a full-blown diabetic?… Continue reading Prediabetes is a “Pre-Diagnosis” of Diabetes

Reactive Oxygen Species (ROS)

Reactive Oxygen Species (ROS) is a type of unstable molecule that contains oxygen and that easily reacts with other molecules in a cell. A buildup of reactive oxygen species in cells may cause damage to DNA, RNA, and proteins, and may cause cell death. Reactive oxygen species are free radicals, also called oxygen radicals. Traditionally,… Continue reading Reactive Oxygen Species (ROS)

Inflammation and Its Outcomes

Despite it being an essential response to infection and tissue injury, inflammation has also been associated with several pathological processes. Excessive acute inflammation causes tissue damage and non-resolving inflammation leads to chronic tissue malfunction, suggesting a delicate balance between the rapid and effective response to distresses in tissue homeostasis and the collateral damage on tissue… Continue reading Inflammation and Its Outcomes

Atherosclerosis or Atheroscleritis

Heart disease is currently one of the major causes of morbidity and correlates closely with the global incidence of obesity and type 2 diabetes. Recently, there is an increasing focus on metainflammation as the primary pathophysiology. Recent studies implicate early metabolic abnormalities (weight gain, insulin resistance, and prehypertension, and irregular blood lipid levels). A basic… Continue reading Atherosclerosis or Atheroscleritis

Chronic Inflammation Metabolic Overfeed Hyperinsulinemia

Despite it being an essential response to infection and tissue injury, inflammation has also been associated with several pathological processes. Excessive acute inflammation causes tissue damage and non-resolving inflammation leads to chronic tissue malfunction, suggesting a delicate balance between the rapid and effective response to distresses in tissue homeostasis and the collateral damage on tissue… Continue reading Chronic Inflammation Metabolic Overfeed Hyperinsulinemia

Obesity: Low Grade Chronic State of Inflammation Proinflammatory Cytokines (TNF-α, IL-6 and CRP)

Obesity is characterized by a low-grade chronic state of inflammation in which the level of pro-inflammatory cytokines such as TNF-α, IL-6, and CRP are increased. It is a state in which there is an over-accumulation of subcutaneous and/or abdominal adipose tissue. This adipose tissue is no longer considered inert and mainly devoted to storing energy;… Continue reading Obesity: Low Grade Chronic State of Inflammation Proinflammatory Cytokines (TNF-α, IL-6 and CRP)

Insulin is The Link Between Adipose Tissue Inflammation and Metabolic Syndrome.

Hyperinsulinemia (HI) serves as the common link between adipose tissue inflammation (ATI) and metabolic syndrome. The obesity-associated metabolic phenotype elevated pro-inflammatory cells (M1 macrophages and NK-cells) suppressed anti-inflammatory cells (M2 macrophages, eosinophils, and regulatory T-cells). Partial reduction of circulating insulin level attenuated excess calorie-induced ATI and improved insulin sensitivity. Mol Cell Endocrinol. 2018 Dec 5;477:15-28.… Continue reading Insulin is The Link Between Adipose Tissue Inflammation and Metabolic Syndrome.

Insulin is The Disease, Glucose is Just The Symptom.

For Type 2 Diabetes to occur, both insulin resistance and comparative inadequate insulin secretion must co-exist. For example, overweight individuals may have insulin resistance, but diabetes only develops in those who cannot increase insulin secretion sufficiently to compensate for their insulin resistance. Unfortunately, this period of hyperinsulinemia prior to the collapse of insulin production permits… Continue reading Insulin is The Disease, Glucose is Just The Symptom.

The Obesity Pandemic

We have an obesity pandemic. This pandemic is shifting cancer to a young person’s disease. In an analysis of disease data from 2000 to 2016, the incidence of obesity-associated cancers (OACs) has shifted to younger individuals. Typically, these cancers are diagnosed at higher rates among people older than 65. The most notable findings pertain to… Continue reading The Obesity Pandemic