Heart disease is currently one of the major causes of morbidity and correlates closely with the global incidence of obesity and type 2 diabetes.
Recently, there is an increasing focus on metainflammation as the primary pathophysiology.
Recent studies implicate early metabolic abnormalities (weight gain, insulin resistance, and prehypertension, and irregular blood lipid levels). A basic description would be that inflammation is secondary to insulin resistance, which in turn leads to obesity which increases the chances of diabetes, high blood pressure, prothrombotic state, and abnormal lipid presence.
