Insulin is The Link Between Adipose Tissue Inflammation and Metabolic Syndrome.

August 3, 2019

Hyperinsulinemia (HI) serves as the common link between adipose tissue inflammation (ATI) and metabolic syndrome.

The obesity-associated metabolic phenotype elevated pro-inflammatory cells (M1 macrophages and NK-cells) suppressed anti-inflammatory cells (M2 macrophages, eosinophils and regulatory T-cells).

Partial reduction of circulating insulin level attenuated excess calorie-induced ATI and improved insulin sensitivity.

Mol Cell Endocrinol. 2018 Dec 5;477:15-28. doi: 10.1016/j.mce.2018.05.010. Epub 2018 May 10.