Hyperinsulinemia (HI) serves as the common link between adipose tissue inflammation (ATI) and metabolic syndrome.
The obesity-associated metabolic phenotype elevated pro-inflammatory cells (M1 macrophages and NK-cells) suppressed anti-inflammatory cells (M2 macrophages, eosinophils, and regulatory T-cells).
Partial reduction of circulating insulin level attenuated excess calorie-induced ATI and improved insulin sensitivity.
Mol Cell Endocrinol. 2018 Dec 5;477:15-28. doi: 10.1016/j.mce.2018.05.010. Epub 2018 May 10.