Hyperinsulinemia Causing Chronic Pain – Gurpreet Padda: Episode 33

Dr. Gurpreet Padda is an interventional pain physician who treats patients with profound, chronic, severe pain that is unrelenting.  Over time he worked out that there was more to these people’s pain than just the physical source of it and that it was also a systemic or metabolic inflammatory issue and that hyperinsulinemia was at […]

Chronic Inflammation Metabolic Overfeed Hyperinsulinemia

Despite it being an essential response to infection and tissue injury, inflammation has also been associated with several pathological processes. Excessive acute inflammation causes tissue damage and non-resolving inflammation leads to chronic tissue malfunction, suggesting a delicate balance between the rapid and effective response to distresses in tissue homeostasis and the collateral damage on tissue […]

Insulin is The Link Between Adipose Tissue Inflammation and Metabolic Syndrome.

Hyperinsulinemia (HI) serves as the common link between adipose tissue inflammation (ATI) and metabolic syndrome. The obesity-associated metabolic phenotype elevated pro-inflammatory cells (M1 macrophages and NK-cells) suppressed anti-inflammatory cells (M2 macrophages, eosinophils, and regulatory T-cells). Partial reduction of circulating insulin level attenuated excess calorie-induced ATI and improved insulin sensitivity. Mol Cell Endocrinol. 2018 Dec 5;477:15-28. […]

“The More Money Doctors Receive…The More Brand-Name Drugs They Tend to Prescribe.”

When we reverse type 2 diabetes, hyperinsulinemia, and obesity, we are advocating for less medical intervention and more patient self-care. Empowering the patient to manage a lifestyle disease with a lifestyle intervention does not result in a medical profit. There is no financial incentive in the Business of Medicine, Big Pharma, or Big Food for […]