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Dopamine

Compulsive overeating is a more classically recognized addiction disorder.

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Dopamine

August 26, 2020

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Compulsive overeating is a more classically recognized addiction disorder.

Dopamine is the recognized neurotransmitter for the classic substance abuse disorders and in the regulation of food reward and the hedonic aspects of appetite.

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The constant signaling from hyper palatable food b

The constant signaling from hyper palatable food barrage promotes grazing behavior, near continuous eating and chronically high levels of insulin.

Unfortunately, the brains perception of nutrient value is distorted by synthetic flavors. The patient (squirrel) ends up over consuming manufactured carbohydrate and manufactured fat in a combination that is highly obesogenic.
#covid #metabolicinflammation #asipp
#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #chronicpain #lowcarb

About COVID-19: We are all going to be exposed to

About COVID-19:

We are all going to be exposed to this virus eventually.

A virus is just a virus, it lacks morality, or politics.

A virus only expresses itself based upon the host’s biochemical capacity.

This particular virus hijacks hosts that are predisposed to metabolic inflammation and have a pre-existing cytokine storm.

We are already getting blood samples for IgG and IgM, which measure the antibody to the virus.

Testing for the virus is mandatory to define its prevalence and spread potential, but the actionable tests are of host biochemistry.

What we should also be evaluating is:
HgBA1C
Insulin Level
Fructosamine
GGT
HS-CRP
ESR
LDL-P
LPIR
Omega 6:3 ratio

We need these tests to determine what the true at risk population, to reduce the damage from the virus. Because we are all going to be exposed to the virus eventually.

Exposure, infection, morbidity and mortality vary widely based upon the host biochemistry.
This virus is merely the spark igniting a bonfire in the presence of accelerants. Let’s take away the accelerants because we live in a world of potential sparks all the time.
Human behavior controls the accelerants, we don’t control the sparks.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #chronicpain #asipp #lowcarb

On average, every single hour of TV viewed after t

On average, every single hour of TV viewed after the age of 25 reduces the viewer's life expectancy by 21.8 (95% UI: 0.3-44.7) min.

Br J Sports Med. 2012 Oct;46(13):927-30. doi: 10.1136/bjsm.2011.085662

#covid #metabolicinflammation #asipp
#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation

The ACE inhibitors The death rate in patients wit

The ACE inhibitors

The death rate in patients with multiple comorbid conditions of metabolic dysfunction are vastly greater than the general population.

Less than 12.2% of the US population does not have severe metabolic inflammation or metabolic dysfunction.

Profoundly, the very drug class that is the preferred for blood pressure management in metabolic syndrome, may dramatically increase Corona virus attachment to the lung alveolar cells [by up regulating surface ACE receptors number] increasing attachment of virus to the cell. You have to have sufficient attachment for the virus to be internalized into the cell and the protease to allow the RNA transmission.

https://www.cebm.net/covid-19/angiotensin-converting-enzyme-ace-inhibitors-and-angiotensin-receptor-blockers-in-covid-19/

#covid #metabolicinflammation #asipp
#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #chronicpain #lowcarb

#covid #metabolicinflammation #cuomo #trump #musk

#covid #metabolicinflammation #cuomo #trump #musk #asipp
#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #chronicpain #lowcarb #ventilator

A study published in Nature, demonstrated that lac

A study published in Nature, demonstrated that lactate is not simply a waste product, but a key regulator of cell functions in Warburg-associated diseases. Lactate changes the function of immune cells macrophages, rewiring them to behave differently.
Lactate is the source and stimulator of a new type of histone modification, which they termed histone lactylation. Histones are a group of proteins that organize DNA into structural units and control which genes are expressed.

Histone lactylation alters the cells from a pro-inflammatory and anti-bacterial state (known as M1) to an anti-inflammatory and reparative state (known as M2). This reparative M2 macrophage presence in tumors is known to promote growth, metastasis and immune suppression in cancer.
Researchers also detected histone lactylation in macrophages isolated from mouse melanoma and lung tumors, and observed positive correlations between histone lactylation and cancer-promoting genes made by reparative M2 macrophages.

High lactate and histone lactylation levels in macrophages may contribute to the formation of tumors and their progression, i.e. The Warburg Effect.

Metabolic Regulation of Gene Expression by Histone Lactylation. Nature, 2019 DOI: 10.1038/s41586-019-1678-1

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #chronicpain #asipp #lowcarb #warburg

Cancer cells consume and use nutrients differently

Cancer cells consume and use nutrients differently than their healthy counterparts. Cells need to generate energy to keep living, but cancer cells have an increased demand for energy in order to grow and multiply quickly, specifically glucose.

90 years ago, German physiologist and physician Otto Warburg knew that normal cells use oxygen to turn food into energy through a process called oxidative phosphorylation. But cancer cells, preferred to fuel growth through glycolysis, a process that involves consuming and breaking down glucose for energy.
The phenomenon was coined "the Warburg effect," the foundation for the field of cancer metabolism and earned Warburg the Nobel Prize in 1931. the Warburg effect occurs in virtually all cancers. Lactate is the end-product of the Warburg effect.

The Warburg effect is also observed in other diseases, including sepsis, autoimmune diseases, atherosclerosis, diabetes and aging.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #chronicpain #asipp #lowcarb #warburg

The very mention of a ketogenic diet can throw som

The very mention of a ketogenic diet can throw some physicians into a tailspin. As physicians we are taught about diabetic ketoacidosis, a potentially life threatening medical emergency. We are not routinely taught about nutritional ketosis, the default human state of existence.

Our brain requires either glucose or ketones as a primary fuel source. Ketones are a vital evolutionary advantage, since we have only about 24 hours storage capacity for glucose or glycogen (500g total), but a nearly unlimited supply of ketones converted from fat. As a species we would have all died out, but for the ability to survive in nutritional ketosis.

Diabetic ketoacidosis occurs when diabetics with no insulin production (usually Type I diabetics, or late-stage insulin-dependent Type II) enter cellular starvation despite high circulating glucose. Without insulin, they can’t get glucose into their cells and start to have organ failure with a drop in pH. They then enter into starvation recovery mode and generate ketones out of fat and proteins. By the time ketone levels approaches 15 to 25 mM, the resulting pH imbalance leads to profound metabolic derangement.

Nutritional ketosis does not have a metabolic derangement, because the feedback loop of insulin clears the blood stream of excessive circulating glucose, and the ketones being produced are used for energy or exhaled. Nutritional ketosis maintains beta-hydroxybutyrate levels between about 0.5 and 3.0 mM, far less than the levels required to cause acid-base abnormalities. Longterm, keto-adaption the brain shifts from being primarily dependent on glucose, to being primarily dependent on beta-hydroxybutyrate.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation

Polycystic ovary syndrome (PCOS) The most common

Polycystic ovary syndrome (PCOS)

The most common endocrine dysfunction of women - affects 10-20% of women.

A life-long disease with enormous medical, emotional and financial consequences.

High risk for diabetes and metabolic syndrome & 80% are overweight/obese.

PCOS is the result of hyperinsulinemia * The effects of insulin on the ovary Theca cells results in release of testosterone * The resulting manifestations have devastating effects (obesity, facial hair, acne, and emotional disorders) on teenage girls * Many cases have been reversed with lifestyle changes that act to lower insulin * IGF plays a role but addressing hyperinsulinemia can reverse the condition and its manifestations

Theca cells endocrine cells in the ovary made up of connective tissue surrounding the follicle. The theca cells are responsible for the production of androstenedione.
Androstenedione is a precursor of testosterone and other androgens, as well as of estrogens like estrone.
Androstenedione has weak androgenic activity.
FSH induces the granulosa cells to make aromatase that converts the androgens made by the theca interna into estradiol.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #PCOS

Why we regain weight after weight loss regain more

Why we regain weight after weight loss
regain more than we lost.
each time you lose weight it becomes more difficult . “rubber banding” or the fat “yo-yo” or relapse-induced hyperplasia of adipose tissue

Weight loss awakens the body's defense system which is focused on the objective of restoring the body's depleted energy reserves.
• Adipocytes shrink during weight loss, but there is no discernible change in the number of adipocytes in adipose tissue.
• But when you regain the weight, they don’t just grow back to normal size, they actually multiply. Metabolic conditions during the relapse to obesity may provide the conditions that promote hyperplasia
• This increase in cell number persisted throughout the relapse process as all of the adipocytes became larger. This increased cell number partially explains animals surpassing their pre-weight loss weight following relapse.

Obes Rev. 2015 Feb; 16(Suppl 1): 45–54.
Published online 2015 Jan 22. doi: 10.1111/obr.12255

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation

#chronicpain
#asipp

ENSURE PRE-SURGERY is specially designed to help r

Patient’s with chronic pain have a signaling mec

Patient’s with chronic pain have a signaling mechanism, whether induced by medications or their endogenous pain, that causes them to seek out dopaminergic stimulation, to relieve their pain.
Some of this dopaminergic stimulation can be substituted by dietary intake.

Excessive nonnutritive dietary intake leads to obesity and visceral adipose tissue accumulation, which is inflammatory.

Excessive inflammatory mediators aggravate pain, and the cycle repeats.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation
#chonicpain
#asipp

Soybean oil not only leads to obesity and diabetes

Soybean oil not only leads to obesity and diabetes, but could also affect neurological conditions such as:

maternal-child bonding
autism
Alzheimer's disease
anxiety
depression

A previous study published in 2015 suggested that soybean oil induced obesity, diabetes, insulin resistance, and fatty liver in mice. A more recent 2020 study published in the journal Endocrinology, compared mice fed diets high in fat: soybean oil, a polyunsaturated fat vs. coconut oil, a saturated fat.

Soybean oil produced pronounced effects on the hypothalamus, which regulates body weight via metabolism, maintains body temperature, is critical for reproduction and physical growth as well as response to stress. Surprisingly, mice fed soybean oil downregulated the gene which produces oxytocin in the hypothalamus, the hormone responsible for mother-child bonding and is also known as the “love” hormone.

Nearly an additional 100 other genes were also affected by the soybean oil diet, which may have ramifications not just for energy balance, but also for brain function and diseases such as autism.

One day we will view industrial seed oils with the same disdain as cigarette smoking…

BTW: Soybean oil is a polyunsaturated fat and is often touted as a healthy option over saturated fats, but the saturated fat from coconut oil, produced very few changes in the hypothalamic genes.

Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice. Endocrinology, 2020; DOI: 10.1210/endocr/bqz044

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #autism

Autism rates increasing, with soybean oil consumpt

Autism rates increasing, with soybean oil consumption.

Soybean oil is the most widely produced and consumed edible oil in the U.S., consumption dramatically increased right before the beginnings of the 1970's

In the 1970s and 1980s, about 1:2,000 children had autism.

Today, the CDC estimates that 1:150 has an autism spectrum disorder, or ASD.

A True Increase or Semantics?

More to come, tomorrow.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation
#autism

Nearly 77% of the US population is now overweight.

Nearly 77% of the US population is now overweight. This dramatic change in the last 50 years is correlated with the availability of highly processed foods, and with a dramatic increase in chronic pain.

In a mouse model, high-calorie foods, which induces dopamine release, disrupted normal feeding schedules, resulting in overconsumption.

Additionally, in the "knockout" mouse model which had dopamine signaling disrupted, didn't seek the dietary “rewarding pleasure,” maintained a normal eating schedule, and did not become obese.

Practical Conclusion:

Diet-induced obesity requires dopamine (DA)-Drd1 signaling

Avoid eating outside a normal eating window, typically less than eight hours out of 24, allowing glycogen depletion in the liver and preventing insulin resistance.

How is this relevant to chronic pain:

I practice in the field of interventional pain, addiction, and obesity/ metainflammation.
1. Patient’s with chronic pain have a signaling mechanism, wether induced by medications or their endogenous pain, that causes them to seek out dopaminergic stimulation, to relieve their pain.

2. Some of this dopaminergic stimulation can be substituted by dietary intake.

3. Excessive non nutritive dietary intake leads to obesity and visceral adipose tissue accumulation, which is inflammatory.

4. Excessive inflammatory mediators aggravate pain, and the cycle repeats.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation

Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding. Current Biology, 2020; DOI: 10.1016/j.cub.2019.11.029

Could sugar self-substitution for opioids in our p

Could sugar self-substitution for opioids in our patient’s be leading to insulin resistance, obesity, T2DM?

In an experiment done on mini-pigs, they found that sugar can affect the brain's reward system in a similar "manner similar to that of drugs of abuse"

Sugar's impact on the brain's reward system boils down to how it affects two types of receptors in the brain.

The first set are dopamine receptors -- dopamine is a central player in the brain's reward system, released during pleasurable activities.
The second set are opioid receptors, which are also found all over the brain, but are particularly found in areas involved in eating-related rewards.
Sensitivity of both receptors was dampened when pigs were allowed unrestricted access to sugar water for one hour each day for twelve days. The pigs were also fed a normal diet, so sugar consumption was unrelated to their caloric needs.

After the fist day, the sugar intake lowered the "availability" of opioid and dopamine receptors, essentially dampening the ability of these receptors to bind to their natural ligands. Both Opiate and Dopamine receptor binding was attenuated 14% in the anterior cingulate cortex and the nucleus accumbent, both are areas of the hedonic reward.

At the end of the 12 days, the scientists found that the pattern held -- the availability of both types of receptors continued to decrease significantly.

Could sugar self-substitution for opioids in our patient’s be leading to insulin resistance, obesity, T2DM?

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation
#chronicpain
#asipp

Winterdahl, M., Noer, O., Orlowski, D. et al. Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain. Sci Rep 9, 16918 (2019) doi:10.1038/s41598-019-53430-9

Adipose tissue-derived proteins known to affect in

Adipose tissue-derived proteins known to affect inflammation

TNF-α
IL-6
IL-1β
Leptin
Adiponectin
Resistin
Acylation-stimulating protein
SAA3
α1 acid glycoprotein
Pentraxin-3
IL-1 receptor antagonist
Macrophage migration inhibitor factor

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation

#chonicpain
#asipp

Prehistoric humans ate bone marrow like canned sou

Prehistoric humans ate bone marrow like canned soup 400,000 years ago.

Bone marrow constitutes a significant source of nutrition, it and the cranial vault contents were the few available highly nutritious resources available for early scavengers humans, who subsisted on remnants from larger predator kills.

The access to this fat likely contributed to the direct development of intelligence and brain growth, as saturated fats were the primary driver of brain growth.

In fact, animal who were inadvertently hunted and found to be lacking sufficient fat were often abandoned.

Direct evidence that early Paleolithic people saved animal bones for up to nine weeks before feasting on them, based upon the translocation of selected body parts of the hunted animal carcasses to the cave structures.

The Paleolithic humans developed preservation strategies for the marrow by covering the bone with skin. The bones were used as 'cans' that preserved the bone marrow for a long period until it was time to take off the dry skin, shatter the bone and eat the marrow.

mmm... yummy

Bone marrow storage and delayed consumption at Middle Pleistocene Qesem Cave, Israel (420 to 200 ka). Science Advances, 2019; 5 (10)

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation #paleo

Degradation of the intrinsic gut microbiome by pro

Degradation of the intrinsic gut microbiome by processed food consumption

The depletion of the microbiome may be associated with the increased prevalence of complex conditions like allergies, autoimmune, anxiety, depression, gastrointestinal diseases, hypertension, diabetes and obesity.

These bacteria exist in a delicate interdependent ecosystem that support our immune system, which protect us from viruses and pathogens, and help us absorb nutrients and produce energy. The complex signaling mechanisms have evolved over millions of years, but have been decimated by hyper processed foods.

In a recent study in Cell Host & Microbe, on the bacteria found in the intestine of a mummified iceman ,Ötzi from the Ötztal Alps. Scientists compared samples of the mummy's bacteria, to the genome of intestinal microorganisms of over 6500 modern individuals from all continents. The microbiome of contemporary non-Westernized populations (from Tanzania and Ghana , which are not used to processed food and have non-Westernized hygiene practices and lifestyle were also compared.

The bacterial shift appears to be related to dietary changes rather than genetic changes, as the modern humans with non westernized diet had more similarity to the ice man.

#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation
#bileacids #crohns

Cell Host & Microbe, 2019; DOI: 10.1016/j.chom.2019.08.018

A change in diet should be the first step for trea

A change in diet should be the first step for treating inflammatory bowel diseases, like Crohn's and other human inflammatory bowel disease (IBD). This is quite similar to canine chronic enteropathy (CE). In a study published in the journal Microbiome, researchers investigated the connection between a prescription diet, the gut microbiome, and successful entry into disease remission in pet dogs.

They used genetic sequencing techniques, to catalog the microbes present in the stool.

They discovered the key features of the microbiome and associated metabolic products which contained elevated secondary bile acids that appeared only in dogs that entered disease remission, a type of bacteria (Clostridium hiranonis) that produces these compounds.

Taking the secondary bile acids found to be associated with remission, the researchers applied them to the E. coli and C. perfringens grown from the sick dogs and found the bile acids inhibited their growth.
They also gave C. hiranonis from the dogs to mice with a form of inflammatory bowel disorder to see if the bacteria could reduce disease in a different animal model.

And comparing the impact of diet on the dog's microbiome with that seen during diet therapy in children with Crohn's, the study team found similarities, with elevations in Clostridium scindens, which, like C. hiranonis, is a potent producer of secondary bile acids.

Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids. Microbiome, 2019; 7 (1)
#vegetableoil #reversediabetes #lowinsulin #ketolifestyleforlife #carnivory #diabetestype2 #intermittentfasting #metabolicinflammation #ketolifestyle #lowcarbideas #zerocarb #ketostl #ketostlouis #lowcarbstlouis #lowinsulindiet #stlouis #stl #metainflammation
#bileacids #crohns

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