Rubber Banding” or The Fat “Yo-Yo” or Relapse-Induced Hyperplasia of Adipose Tissue
Why we regain weight after weight loss regains more than we lost. Each time you lose weight it becomes more difficult . “rubber banding” or the fat “yo-yo” or relapse-induced hyperplasia of adipose tissue. Weight loss awakens the body’s defense system which is focused on the objective of restoring the body’s depleted energy reserves. • […]
Metabolic Signals And Innate Immune Activation In Obesity
The interplay between immunity, inflammation, and metabolic changes is a growing field of research. Exciting new evidence is emerging with regard to their role in the regulation of metabolism and the activation of inflammatory pathways during the progression of metabolic disorders such as Type 2 Diabetes and Atherosclerosis. The innate immune system The innate immune system […]
Understanding The Role Of Metabolic Inflammation Plays In Obesity And Diabesity
Obesity is a disease that has plagued the modern-day man in recent times. Access to highly processed foods and a decrease in physical activity are key contributors to this ailment. Researchers are hard at work looking into what other underlying factors lead to obesity, especially given its relationship with the onset of Type 2 Diabetes, […]
Inflammatory Cytokines From Fat Tissue
Adipose tissue-derived proteins known to affect inflammation TNF-α IL-6 IL-1β Leptin Adiponectin Resistin Acylation-stimulating protein SAA3 α1 acid glycoprotein Pentraxin-3 IL-1 receptor antagonist Macrophage migration inhibitory factor.
Does Sugar Consumption Cause Obesity?
Sugar has been vilified over the years with claims of its disastrous effects on our health. Are these claims true? Does taken a soda a day guarantee one ill health? What of the effects of excess sugar on obesity? In this article, we will explore these claims and determine whether indeed excessive sugar intake leads […]
Dual Burden of Malnutrition Obesity Starvation
It is estimated that by 2020, two-thirds of the global burden of disease will be due to chronic non-communicable diseases, most of which are associated with diet. While hunger is a tremendous global health concern that cannot be minimized, overnutrition should similarly be given concentrated attention. Malnutrition affects up-to 1 billion people. Even though undernutrition […]
Inflammation and Its Outcomes
Despite it being an essential response to infection and tissue injury, inflammation has also been associated with several pathological processes. Excessive acute inflammation causes tissue damage and non-resolving inflammation leads to chronic tissue malfunction, suggesting a delicate balance between the rapid and effective response to distresses in tissue homeostasis and the collateral damage on tissue […]
Atherosclerosis or Atheroscleritis
Heart disease is currently one of the major causes of morbidity and correlates closely with the global incidence of obesity and type 2 diabetes. Recently, there is an increasing focus on metainflammation as the primary pathophysiology. Recent studies implicate early metabolic abnormalities (weight gain, insulin resistance, and prehypertension, and irregular blood lipid levels). A basic […]
Chronic Inflammation Metabolic Overfeed Hyperinsulinemia
Despite it being an essential response to infection and tissue injury, inflammation has also been associated with several pathological processes. Excessive acute inflammation causes tissue damage and non-resolving inflammation leads to chronic tissue malfunction, suggesting a delicate balance between the rapid and effective response to distresses in tissue homeostasis and the collateral damage on tissue […]
Obesity: Low Grade Chronic State of Inflammation Proinflammatory Cytokines (TNF-α, IL-6 and CRP)
Obesity is characterized by a low-grade chronic state of inflammation in which the level of pro-inflammatory cytokines such as TNF-α, IL-6, and CRP are increased. It is a state in which there is an over-accumulation of subcutaneous and/or abdominal adipose tissue. This adipose tissue is no longer considered inert and mainly devoted to storing energy; […]