Pain is the leading reason why people come to my practice, and it is the common link between untreated metabolic syndrome and untreated diabetes. I personally evaluate and treat several thousand patients per year for chronic pain, in an urban setting where access to high-intensity healthcare is readily available through several large academic centers as well as governmental sponsored outreach clinics. Unfortunately, despite the availability of cutting edge medical treatment, overall health of individuals and populations continues to decline each year. Over 90% of the patients have untreated metabolic syndrome and over 60% have undiagnosed pre-diabetes or type 2 diabetes. Pain is the final common symptom for the human body to signal impending tissue damage, and most patients avoid contact with the health delivery system until they develop a symptom that they can no longer ignore. Unfortunately, my clinical practice is not unique; pain is the leading reason for patients seeking medical care and is one of the most disabling, burdensome, and costly conditions in the United States. Overall, pain care/treatment and lost productivity costs the U.S. $635 billion per year. Hyper-inflammation is the common link in metabolic syndrome and chronic pain.