Cellular metabolic overactivity leads to metal inflammation.
The immune system protects us from infections and tumors. the linkage between metabolism and inflammation, which seems clinically evident, has been elusive to demonstrate from a biochemical pathway perspective.
Researchers demonstrated that the metabolic activity in the immune cells of primary immunodeficiency disorders (PID) patients is significantly up-regulated, with resulting increased cellular respiration. This then signaled the cells to produce inflammatory mediators.
This study identified the pathway for pathological mitochondrial retrograde signaling leading to metal inflammation.
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2. Nature Immunology, 2019